No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
KRA_PSY_ANYMENTAL
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F90-F98
Name in latin
Perturbationes hyperkineticae
Similar endpoints
↥List of similar endpoints to
Hyperkinetic disorders
based on the number of shared cases.
Similar with more cases:
- Hyperkinetic disorders
- Any mental disorder
- Psychiatric diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 85568 | 27816 | 57544 |
| Only index persons | 72271 | 24907 | 47364 |
| Unadjusted period prevalence (%) | |||
| Whole population | 1.34 | 0.80 | 1.61 |
| Only index persons | 1.50 | 0.92 | 1.81 |
| Median age at first event (years) | |||
| Whole population | 13.08 | 18.72 | 10.28 |
| Only index persons | 14.82 | 20.68 | 11.74 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3964 | 2365 | 1599 |
| Unadjusted period prevalence (%) | 0.88 | 0.93 | 0.80 |
| Median age at first event (years) | 29.19 | 31.16 | 26.28 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint KRA_PSY_HYPERKIN_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_HYPERKIN_EXMORE | 2.539 [1.97, 3.28] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.435 |
During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 16360 females with KRA_PSY_HYPERKIN_EXMORE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| KRA_PSY_HYPERKIN_EXMORE | 3.076 [2.63, 3.6] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 539 out of 42012 males with KRA_PSY_HYPERKIN_EXMORE died.
Mortality risk
Mortality risk for people of age
years, who have KRA_PSY_HYPERKIN_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.278% | 0.568% |
| 5 | 1.423% | 3.502% |
| 10 | 3.985% | 8.713% |
| 15 | 7.412% | 16.325% |
| 20 | 12.296% | 25.947% |
Relationships between endpoints
↥Index endpoint: KRA_PSY_HYPERKIN_EXMORE – Hyperkinetic disorders
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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