No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2800 |
4. Check minimum number of eventsNone |
2800 |
5. Include endpoints |
2870 |
6. Filter based on genotype QC (FinnGen only) |
2754 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E70-E90
Name in latin
Perturbationes metabolismi mineralium
Similar endpoints
↥List of similar endpoints to
Disorders of mineral metabolism
based on the number of shared cases.
Similar with more cases:
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 20513 | 11800 | 8560 |
| Only index persons | 17898 | 10452 | 7446 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.30 | 0.34 | 0.24 |
| Only index persons | 0.34 | 0.38 | 0.28 |
| Median age at first event (years) | |||
| Whole population | 64.04 | 65.92 | 61.47 |
| Only index persons | 63.59 | 65.28 | 61.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2754 | 1559 | 1195 |
| Unadjusted period prevalence (%) | 0.61 | 0.61 | 0.60 |
| Median age at first event (years) | 61.95 | 61.06 | 63.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_MINERAL_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_MET | 2.617 [2.34, 2.93] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.322 |
During the follow-up period (1.1.1998 — 31.12.2019), 3027 out of 8828 females with E4_MINERAL_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MINERAL_MET | 3.794 [3.25, 4.43] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 2295 out of 5987 males with E4_MINERAL_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_MINERAL_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.258% | 0.65% |
| 5 | 1.569% | 4.37% |
| 10 | 4.004% | 10.145% |
| 15 | 7.557% | 18.812% |
| 20 | 12.678% | 31.367% |
Relationships between endpoints
↥Index endpoint: E4_MINERAL_MET – Disorders of mineral metabolism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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