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Disorder of mineral metabolism, other/unspecified

DOID Endpoint Browser PheWeb

E4_MINERAL_METNAS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E83.8, E83.9
  • Hospital discharge: ICD-9 — 275[8-9]
  • Hospital discharge: ICD-8 — 27340
  • Cause of death: ICD-10 — E83.8, E83.9
  • Cause of death: ICD-9 — 275[8-9]
  • Cause of death: ICD-8 — 27340

2 out of 7 registries used, show all original rules.

76

4. Check minimum number of events

None

76

5. Include endpoints

None

76

6. Filter based on genotype QC (FinnGen only)

70

Control definitions (FinnGen only)

Control exclude E4_METABOLIA

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 666 410 245
Only index persons 511 317 194
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 54.70 57.04 49.92
Only index persons 49.20 51.04 46.21

-FinnGen-

Key figures

All Female Male
Number of individuals 70 39 31
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 42.77 37.50 49.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint E4_MINERAL_METNAS and mortality.

Females

Parameter HR [95% CI] p-value
E4_MINERAL_METNAS 2.427 [1.76, 3.35] < 0.001
Birth year 0.997 [0.99, 1.01] 0.434

During the follow-up period (1.1.1998 — 31.12.2019), 106 out of 288 females with E4_MINERAL_METNAS died.

Males

Parameter HR [95% CI] p-value
E4_MINERAL_METNAS 2.509 [1.54, 4.09] < 0.001
Birth year 0.989 [0.98, 1.0] 0.018

During the follow-up period (1.1.1998 — 31.12.2019), 56 out of 165 males with E4_MINERAL_METNAS died.

Mortality risk

Mortality risk for people of age

years, who have E4_MINERAL_METNAS.

N-year risk Females Males
1 0.324% 0.54%
5 1.49% 3.009%
10 3.687% 7.367%
15 6.926% 14.128%
20 11.9% 23.356%

Relationships between endpoints

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Index endpoint: E4_MINERAL_METNAS – Disorder of mineral metabolism, other/unspecified

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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