No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
200 |
4. Check minimum number of eventsNone |
200 |
5. Include endpointsNone |
200 |
6. Filter based on genotype QC (FinnGen only) |
198 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E83
Name in latin
Perturbationes metabolismi magnesii
Similar endpoints
↥List of similar endpoints to
Disorders of magnesium metabolism
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1471 | 688 | 778 |
| Only index persons | 1406 | 660 | 746 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 64.94 | 65.77 | 64.25 |
| Only index persons | 65.12 | 66.02 | 64.32 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 198 | 89 | 109 |
| Unadjusted period prevalence (%) | 0.05 | 0.03 | 0.05 |
| Median age at first event (years) | 66.88 | 63.36 | 69.76 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_MG_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MG_MET | 6.28 [3.89, 10.13] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.391 |
During the follow-up period (1.1.1998 — 31.12.2019), 185 out of 478 females with E4_MG_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_MG_MET | 8.216 [5.17, 13.05] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 237 out of 529 males with E4_MG_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_MG_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.659% | 1.418% |
| 5 | 3.779% | 8.106% |
| 10 | 8.898% | 19.789% |
| 15 | 16.579% | 34.075% |
| 20 | 28.077% | 50.984% |
Relationships between endpoints
↥Index endpoint: E4_MG_MET – Disorders of magnesium metabolism
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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