No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
3 out of 7 registries used, show all original rules. |
149 |
4. Check minimum number of eventsNone |
149 |
5. Include endpointsNone |
149 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
Control exclude
E4_METABOLIA
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E83
Name in latin
Perturbationes metabolismi phosphori
Similar endpoints
↥List of similar endpoints to
Disorders of phosphorus metabolism and phosphatases
based on the number of shared cases.
Similar with more cases:
- Disorders of mineral metabolism
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 908 | 443 | 459 |
| Only index persons | 819 | 399 | 420 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.02 | 0.01 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 54.06 | 52.80 | 55.17 |
| Only index persons | 54.59 | 53.52 | 55.61 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 79 | 63 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | 50.23 | 47.40 | 53.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_PHOS_MET and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 4.82 [3.0, 7.74] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.274 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 333 females with E4_PHOS_MET died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PHOS_MET | 3.918 [2.62, 5.86] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.048 |
During the follow-up period (1.1.1998 — 31.12.2019), 99 out of 326 males with E4_PHOS_MET died.
Mortality risk
Mortality risk for people of age
years, who have E4_PHOS_MET.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.415% | 0.867% |
| 5 | 2.335% | 4.788% |
| 10 | 6.908% | 11.571% |
| 15 | 13.29% | 21.978% |
| 20 | 22.891% | 36.068% |
Relationships between endpoints
↥Index endpoint: E4_PHOS_MET – Disorders of phosphorus metabolism and phosphatases
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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