No definition available.
Other disorders of glucose regulation and pancreatic internal secretion
DOID EFO Endpoint Browser PheWeb
E4_GLUCOPANCREAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
2765 |
4. Check minimum number of eventsNone |
2765 |
5. Include endpoints |
3182 |
6. Filter based on genotype QC (FinnGen only) |
3087 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Other disorders of glucose regulation and pancreatic internal secretion
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 28409 | 13478 | 14612 |
| Only index persons | 21431 | 10325 | 11106 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.39 | 0.41 |
| Only index persons | 0.40 | 0.38 | 0.42 |
| Median age at first event (years) | |||
| Whole population | 57.88 | 59.79 | 55.92 |
| Only index persons | 54.88 | 54.75 | 55.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3087 | 1503 | 1584 |
| Unadjusted period prevalence (%) | 0.70 | 0.59 | 0.80 |
| Median age at first event (years) | 51.33 | 44.63 | 57.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_GLUCOPANCREAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GLUCOPANCREAS | 3.204 [2.86, 3.59] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.033 |
During the follow-up period (1.1.1998 — 31.12.2019), 4039 out of 9419 females with E4_GLUCOPANCREAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_GLUCOPANCREAS | 3.788 [3.33, 4.31] | < 0.001 |
| Birth year | 0.986 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 4535 out of 10415 males with E4_GLUCOPANCREAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_GLUCOPANCREAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.279% | 0.771% |
| 5 | 1.637% | 3.895% |
| 10 | 4.176% | 10.189% |
| 15 | 7.826% | 18.174% |
| 20 | 12.882% | 29.84% |
Relationships between endpoints
↥Index endpoint: E4_GLUCOPANCREAS – Other disorders of glucose regulation and pancreatic internal secretion
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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