No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
546 |
4. Check minimum number of eventsNone |
546 |
5. Include endpointsNone |
546 |
6. Filter based on genotype QC (FinnGen only) |
530 |
Control definitions (FinnGen only)
Control exclude
E4_GLUCOPANCREAS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E16
Name in latin
Hypoglychaemia ex medicamento sine comate
Similar endpoints
↥List of similar endpoints to
Drug-induced hypoglycaemia without coma
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4342 | 1947 | 2352 |
| Only index persons | 3451 | 1539 | 1912 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.07 |
| Only index persons | 0.07 | 0.06 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 67.85 | 72.85 | 63.76 |
| Only index persons | 67.13 | 71.38 | 63.71 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 530 | 225 | 305 |
| Unadjusted period prevalence (%) | 0.13 | 0.09 | 0.15 |
| Median age at first event (years) | 60.10 | 55.21 | 63.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPODRUG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPODRUG | 3.179 [2.59, 3.9] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.425 |
During the follow-up period (1.1.1998 — 31.12.2019), 810 out of 1499 females with E4_HYPODRUG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPODRUG | 4.327 [3.31, 5.66] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 853 out of 1762 males with E4_HYPODRUG died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPODRUG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.291% | 0.724% |
| 5 | 1.778% | 4.777% |
| 10 | 4.592% | 11.687% |
| 15 | 9.211% | 21.543% |
| 20 | 16.109% | 34.332% |
Relationships between endpoints
↥Index endpoint: E4_HYPODRUG – Drug-induced hypoglycaemia without coma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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