No definition available.
Disorder of pancreatic internal secretion, other and/or unspecified
DOID EFO Endpoint Browser PheWeb
E4_PANCSECNAS
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
232 |
4. Check minimum number of eventsNone |
232 |
5. Include endpointsNone |
232 |
6. Filter based on genotype QC (FinnGen only) |
226 |
Control definitions (FinnGen only)
Control exclude
E4_GLUCOPANCREAS
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Disorder of pancreatic internal secretion, other and/or unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of glucose regulation and pancreatic internal secretion
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1896 | 1059 | 820 |
| Only index persons | 1511 | 896 | 615 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 44.97 | 39.12 | 52.19 |
| Only index persons | 42.06 | 36.45 | 50.25 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 226 | 142 | 84 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 41.28 | 34.86 | 52.15 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint E4_PANCSECNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 2.933 [2.09, 4.12] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.055 |
During the follow-up period (1.1.1998 — 31.12.2019), 166 out of 473 females with E4_PANCSECNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PANCSECNAS | 4.546 [3.15, 6.57] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 479 males with E4_PANCSECNAS died.
Mortality risk
Mortality risk for people of age
years, who have E4_PANCSECNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.191% | 0.945% |
| 5 | 1.541% | 5.339% |
| 10 | 4.135% | 12.739% |
| 15 | 7.215% | 22.267% |
| 20 | 12.337% | 36.003% |
Relationships between endpoints
↥Index endpoint: E4_PANCSECNAS – Disorder of pancreatic internal secretion, other and/or unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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