No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
144 |
4. Check minimum number of eventsNone |
144 |
5. Include endpointsNone |
144 |
6. Filter based on genotype QC (FinnGen only) |
142 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Drug-induced gout
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2039 | 925 | 1082 |
| Only index persons | 1283 | 594 | 689 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.02 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 75.80 | 79.20 | 72.91 |
| Only index persons | 74.55 | 78.74 | 70.93 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 142 | 45 | 97 |
| Unadjusted period prevalence (%) | 0.04 | 0.02 | 0.05 |
| Median age at first event (years) | 70.27 | 73.99 | 68.54 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DRUGADVERS_GOUT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_GOUT | 2.636 [2.17, 3.21] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.103 |
During the follow-up period (1.1.1998 — 31.12.2019), 583 out of 777 females with DRUGADVERS_GOUT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DRUGADVERS_GOUT | 2.856 [2.31, 3.53] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 683 out of 935 males with DRUGADVERS_GOUT died.
Mortality risk
Mortality risk for people of age
years, who have DRUGADVERS_GOUT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.264% | 0.645% |
| 5 | 1.546% | 3.143% |
| 10 | 3.113% | 7.409% |
| 15 | 6.06% | 14.055% |
| 20 | 11.075% | 22.563% |
Relationships between endpoints
↥Index endpoint: DRUGADVERS_GOUT – Drug-induced gout
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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