juvenile dermatomyositis: Juvenile dermatomyositis (JDM) is the early-onset form of dermatomyositis (DM, see this term), a systemic, autoimmune inflammatory muscle disorder, characterized by proximal muscle weakness, evocative skin lesion, and systemic manifestations.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
477 |
6. Filter based on genotype QC (FinnGen only) |
459 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Dermatopolymyositis (FG)
based on the number of shared cases.
Similar with more cases:
- Dermatopolymyositis
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3476 | 2143 | 1288 |
| Only index persons | 2514 | 1586 | 928 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.06 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.02 | 59.14 | 58.69 |
| Only index persons | 55.63 | 55.68 | 55.54 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 459 | 282 | 177 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.09 |
| Median age at first event (years) | 56.07 | 54.67 | 58.30 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint DERMATOPOLY_FG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DERMATOPOLY_FG | 2.299 [1.97, 2.68] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.13 |
During the follow-up period (1.1.1998 — 31.12.2019), 396 out of 1305 females with DERMATOPOLY_FG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| DERMATOPOLY_FG | 2.482 [2.06, 3.0] | < 0.001 |
| Birth year | 0.984 [0.97, 0.99] | 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 812 males with DERMATOPOLY_FG died.
Mortality risk
Mortality risk for people of age
years, who have DERMATOPOLY_FG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.186% | 0.452% |
| 5 | 1.199% | 2.697% |
| 10 | 3.158% | 6.784% |
| 15 | 5.816% | 11.73% |
| 20 | 10.511% | 19.65% |
Relationships between endpoints
↥Index endpoint: DERMATOPOLY_FG – Dermatopolymyositis (FG)
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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