dermatomyositis: Dermatomyositis (DM) is a type of idiopathic inflammatory myopathy characterized by evocative skin lesions and symmetrical proximal muscle weakness.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
163 |
4. Check minimum number of eventsNone |
163 |
5. Include endpointsNone |
163 |
6. Filter based on genotype QC (FinnGen only) |
157 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M33
Name in latin
Alia dermatomyositis
Similar endpoints
↥List of similar endpoints to
Other dermatomyositis
based on the number of shared cases.
Similar with more cases:
- Dermatopolymyositis (FG)
- Dermatopolymyositis
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 994 | 672 | 312 |
| Only index persons | 759 | 525 | 234 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.01 |
| Only index persons | 0.02 | 0.02 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 54.13 | 53.64 | 54.89 |
| Only index persons | 51.33 | 51.38 | 51.23 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 157 | 110 | 47 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.02 |
| Median age at first event (years) | 53.47 | 52.73 | 55.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint M13_DERMATOMYOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DERMATOMYOTH | 2.82 [2.11, 3.76] | < 0.001 |
| Birth year | 1.001 [0.99, 1.01] | 0.762 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 411 females with M13_DERMATOMYOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_DERMATOMYOTH | 3.103 [2.28, 4.22] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 69 out of 201 males with M13_DERMATOMYOTH died.
Mortality risk
Mortality risk for people of age
years, who have M13_DERMATOMYOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.228% | 0.515% |
| 5 | 1.755% | 3.094% |
| 10 | 4.592% | 7.916% |
| 15 | 9.262% | 14.67% |
| 20 | 16.456% | 24.478% |
Relationships between endpoints
↥Index endpoint: M13_DERMATOMYOTH – Other dermatomyositis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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