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Polymyositis

DOID EFO Endpoint Browser PheWeb

M13_POLYMYO

myositis: An inflammatory disease involving a pathogenic inflammatory response in the muscle tissue.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — M33.2
  • Hospital discharge: ICD-9 — 7104
  • Hospital discharge: ICD-8 — 7161
  • Cause of death: ICD-10 — M33.2
  • Cause of death: ICD-9 — 7104
  • Cause of death: ICD-8 — 7161

2 out of 7 registries used, show all original rules.

271

4. Check minimum number of events

None

271

5. Include endpoints

None

271

6. Filter based on genotype QC (FinnGen only)

261

Control definitions (FinnGen only)

Control exclude M13_SYSTCONNECT

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 M33
Name in latin Polymyositis

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2237 1327 876
Only index persons 1502 917 585
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.03 0.03 0.02
Median age at first event (years)
Whole population 60.94 61.53 59.95
Only index persons 57.28 57.97 56.19

-FinnGen-

Key figures

All Female Male
Number of individuals 261 159 102
Unadjusted period prevalence (%) 0.06 0.06 0.05
Median age at first event (years) 56.36 56.08 56.80

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint M13_POLYMYO and mortality.

Females

Parameter HR [95% CI] p-value
M13_POLYMYO 2.097 [1.76, 2.5] < 0.001
Birth year 0.994 [0.99, 1.0] 0.186

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 750 females with M13_POLYMYO died.

Males

Parameter HR [95% CI] p-value
M13_POLYMYO 2.472 [2.02, 3.03] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 217 out of 521 males with M13_POLYMYO died.

Mortality risk

Mortality risk for people of age

years, who have M13_POLYMYO.

N-year risk Females Males
1 0.119% 0.47%
5 1.131% 2.714%
10 2.947% 6.901%
15 5.887% 13.095%
20 10.067% 21.454%

Relationships between endpoints

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Index endpoint: M13_POLYMYO – Polymyositis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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