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Other combined immunodeficiencies

D3_OCID

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D81.8
  • Cause of death: ICD-10 D81.8

2 out of 7 registries used, show all original rules.

47

4. Check minimum number of events

None

47

5. Include endpoints

None

47

6. Filter based on genotype QC (FinnGen only)

44

Control definitions (FinnGen only)

Control exclude D3_IMMUNEMECHANISM

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D81
Name in latin Aliae deficientiae immunales mixtae specificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 294 155 138
Only index persons 247 137 110
Unadjusted period prevalence (%)
Whole population 0.00 0.00 0.00
Only index persons 0.00 0.01 0.00
Median age at first event (years)
Whole population 57.07 57.06 57.39
Only index persons 56.21 56.30 56.10

-FinnGen-

Key figures

All Female Male
Number of individuals 44 26 18
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 55.09 56.23 53.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint D3_OCID and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
D3_OCID 2.764 [1.72, 4.44] < 0.001
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 54 out of 122 males with D3_OCID died.

Mortality risk

Mortality risk for people of age

years, who have D3_OCID.

N-year risk Females Males
1 No data 0.54%
5 No data 3.146%
10 No data 7.953%
15 No data 14.981%
20 No data 24.348%

Relationships between endpoints

Index endpoint: D3_OCID – Other combined immunodeficiencies

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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