This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Lymphocyte function antigen-1 [LFA-1] defect
D3_LYMPHOANTIGEN1DEF
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
33 |
4. Check minimum number of eventsNone |
33 |
5. Include endpointsNone |
33 |
6. Filter based on genotype QC (FinnGen only) |
31 |
Control definitions (FinnGen only)
Control exclude
D3_IMMUNEMECHANISM
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D84
Name in latin
Deficientia antigeni 1 functionis lymphocytorum
Similar endpoints
↥List of similar endpoints to
Lymphocyte function antigen-1 [LFA-1] defect
based on the number of shared cases.
Similar with more cases:
- Other immunodeficiencies
- Immunodeficiencies
- Certain disorders involving the immune mechanism
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 457 | 301 | 152 |
| Only index persons | 324 | 210 | 114 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 72.31 | 73.57 | 69.59 |
| Only index persons | 70.92 | 72.46 | 68.07 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 31 | 14 | 17 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 67.28 | 62.93 | 70.86 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint D3_LYMPHOANTIGEN1DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_LYMPHOANTIGEN1DEF | 1.865 [1.44, 2.41] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.118 |
During the follow-up period (1.1.1998 — 31.12.2019), 162 out of 259 females with D3_LYMPHOANTIGEN1DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_LYMPHOANTIGEN1DEF | 1.915 [1.3, 2.81] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 79 out of 132 males with D3_LYMPHOANTIGEN1DEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_LYMPHOANTIGEN1DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.226% | 0.398% |
| 5 | 1.029% | 2.144% |
| 10 | 2.443% | 5.328% |
| 15 | 4.653% | 9.974% |
| 20 | 8.153% | 16.766% |
Relationships between endpoints
↥Index endpoint: D3_LYMPHOANTIGEN1DEF – Lymphocyte function antigen-1 [LFA-1] defect
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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