This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Chronic drug-induced interstitial lung disorders
CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
48 |
4. Check minimum number of eventsNone |
48 |
5. Include endpointsNone |
48 |
6. Filter based on genotype QC (FinnGen only) |
48 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Chronic drug-induced interstitial lung disorders
based on the number of shared cases.
Similar with more cases:
- Respiratory conditions due to other external agents
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 444 | 290 | 152 |
| Only index persons | 328 | 215 | 113 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.00 |
| Only index persons | 0.01 | 0.01 | 0.00 |
| Median age at first event (years) | |||
| Whole population | 73.02 | 75.38 | 68.75 |
| Only index persons | 71.67 | 74.75 | 65.82 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 48 | 26 | 22 |
| Unadjusted period prevalence (%) | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | 63.74 | 62.09 | 65.70 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
Mortality – FinRegistry
↥Association
Association between endpoint CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD | 2.051 [1.56, 2.7] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.297 |
During the follow-up period (1.1.1998 — 31.12.2019), 160 out of 262 females with CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.17% | No data |
| 5 | 1.353% | No data |
| 10 | 3.344% | No data |
| 15 | 6.493% | No data |
| 20 | 11.182% | No data |
Relationships between endpoints
↥Index endpoint: CHRONIC_DRUGADVERS_INTERSTITIAL_LUNG_DISORD – Chronic drug-induced interstitial lung disorders
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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