No definition available.
Acute drug-induced interstitial lung disorder
ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
233 |
4. Check minimum number of eventsNone |
233 |
5. Include endpointsNone |
233 |
6. Filter based on genotype QC (FinnGen only) |
227 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF5
Similar endpoints
↥List of similar endpoints to
Acute drug-induced interstitial lung disorder
based on the number of shared cases.
Similar with more cases:
- Respiratory conditions due to other external agents
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Other pulmonary diagnosis
- Excluding asthma or asthma-COPD overlap
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2095 | 1174 | 893 |
| Only index persons | 1591 | 915 | 676 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 71.85 | 72.84 | 70.45 |
| Only index persons | 70.45 | 71.25 | 69.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 227 | 111 | 116 |
| Unadjusted period prevalence (%) | 0.05 | 0.04 | 0.06 |
| Median age at first event (years) | 67.44 | 63.83 | 70.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD | 2.16 [1.79, 2.61] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.097 |
During the follow-up period (1.1.1998 — 31.12.2019), 543 out of 1003 females with ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD | 3.019 [2.39, 3.81] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.103 |
During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 739 males with ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD died.
Mortality risk
Mortality risk for people of age
years, who have ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.208% | 0.651% |
| 5 | 1.326% | 4.207% |
| 10 | 3.024% | 10.044% |
| 15 | 5.758% | 18.972% |
| 20 | 10.277% | 30.484% |
Relationships between endpoints
↥Index endpoint: ACUTE_DRUGADVERS_INTERSTITIAL_LUNG_DISORD – Acute drug-induced interstitial lung disorder
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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