Benign neoplasm of urinary organs

CD2_BENIGN_URINARY

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D30
  • Cause of death: ICD-10 D30

2 out of 7 registries used, show all original rules.

1324

4. Check minimum number of events

None

1324

5. Include endpoints

1480

6. Filter based on genotype QC (FinnGen only)

1423

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D10-D36
Name in latin Neoplasmata benigna organorum urinariorum

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10630 5830 4676
Only index persons 8788 5122 3666
Unadjusted period prevalence (%)
Whole population 0.15 0.17 0.13
Only index persons 0.17 0.19 0.14
Median age at first event (years)
Whole population 62.94 61.07 65.27
Only index persons 61.73 59.80 64.43

-FinnGen-

Key figures

All Female Male
Number of individuals 1423 789 634
Unadjusted period prevalence (%) 0.31 0.31 0.32
Median age at first event (years) 61.41 57.32 66.50

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_URINARY and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY 1.337 [1.19, 1.5] < 0.001
Birth year 0.996 [0.99, 1.0] 0.32

During the follow-up period (1.1.1998 — 31.12.2019), 899 out of 4105 females with CD2_BENIGN_URINARY died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY 1.422 [1.26, 1.61] < 0.001
Birth year 0.991 [0.98, 1.0] 0.059

During the follow-up period (1.1.1998 — 31.12.2019), 1092 out of 3120 males with CD2_BENIGN_URINARY died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_URINARY.

N-year risk Females Males
1 0.09% 0.272%
5 0.73% 1.823%
10 1.935% 4.401%
15 3.666% 8.57%
20 6.835% 14.215%

Relationships between endpoints

Index endpoint: CD2_BENIGN_URINARY – Benign neoplasm of urinary organs

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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