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Benign neoplasm: Urinary organ, other/unspecified

DOID Endpoint Browser PheWeb

CD2_BENIGN_URINARY_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D30.7&, D30.9&
  • Hospital discharge: ICD-9 — 223[8-9]
  • Hospital discharge: ICD-8 — 223[8-9]
  • Cause of death: ICD-10 — D30.7&, D30.9&
  • Cause of death: ICD-9 — 223[8-9]
  • Cause of death: ICD-8 — 223[8-9]

2 out of 7 registries used, show all original rules.

90

4. Check minimum number of events

None

90

5. Include endpoints

None

90

6. Filter based on genotype QC (FinnGen only)

87

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 991 579 393
Only index persons 703 426 277
Unadjusted period prevalence (%)
Whole population 0.01 0.02 0.01
Only index persons 0.01 0.02 0.01
Median age at first event (years)
Whole population 58.75 57.59 60.12
Only index persons 53.30 53.31 53.29

-FinnGen-

Key figures

All Female Male
Number of individuals 87 52 35
Unadjusted period prevalence (%) 0.02 0.02 0.02
Median age at first event (years) 48.95 43.95 56.39

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint CD2_BENIGN_URINARY_NOS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY_NOS 2.076 [1.53, 2.81] < 0.001
Birth year 0.992 [0.98, 1.0] 0.075

During the follow-up period (1.1.1998 — 31.12.2019), 107 out of 274 females with CD2_BENIGN_URINARY_NOS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_URINARY_NOS 1.753 [1.16, 2.64] 0.007
Birth year 0.989 [0.98, 1.0] 0.017

During the follow-up period (1.1.1998 — 31.12.2019), 88 out of 186 males with CD2_BENIGN_URINARY_NOS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_URINARY_NOS.

N-year risk Females Males
1 0.158% 0.392%
5 1.142% 2.311%
10 2.997% 5.351%
15 5.58% 10.066%
20 9.505% 17.181%

Relationships between endpoints

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Index endpoint: CD2_BENIGN_URINARY_NOS – Benign neoplasm: Urinary organ, other/unspecified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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