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Benign neoplasm: Renal pelvis

CD2_BENIGN_RENALPELVIS

kidney neoplasm: A benign or malignant neoplasm affecting the kidney. Representative examples of benign renal neoplasms include fibroma, lipoma, oncocytoma, and juxtaglomerular cell tumor. Representative examples of malignant renal neoplasms include renal cell carcinoma, renal pelvis carcinoma, Wilms tumor, rhabdoid tumor, sarcoma, and lymphoma.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D30.1&
  • Hospital discharge: ICD-9 2231
  • Hospital discharge: ICD-8 2231
  • Cause of death: ICD-10 D30.1&
  • Cause of death: ICD-9 2231
  • Cause of death: ICD-8 2231

2 out of 7 registries used, show all original rules.

48

4. Check minimum number of events

None

48

5. Include endpoints

None

48

6. Filter based on genotype QC (FinnGen only)

48

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 D30
Name in latin Neoplasma benignum pelvis renalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 433 243 179
Only index persons 327 197 130
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.01
Only index persons 0.01 0.01 0.00
Median age at first event (years)
Whole population 66.97 65.17 69.25
Only index persons 65.81 64.03 68.50

-FinnGen-

Key figures

All Female Male
Number of individuals 48 29 19
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 60.42 53.30 71.30

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

Association

Association between endpoint CD2_BENIGN_RENALPELVIS and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_RENALPELVIS 2.195 [1.51, 3.2] < 0.001
Birth year 0.995 [0.99, 1.0] 0.211

During the follow-up period (1.1.1998 — 31.12.2019), 71 out of 169 females with CD2_BENIGN_RENALPELVIS died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_RENALPELVIS 2.034 [1.28, 3.22] 0.003
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 64 out of 125 males with CD2_BENIGN_RENALPELVIS died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_RENALPELVIS.

N-year risk Females Males
1 0.193% 0.366%
5 1.243% 2.299%
10 3.296% 5.613%
15 5.789% 10.899%
20 10.092% 17.7%

Relationships between endpoints

Index endpoint: CD2_BENIGN_RENALPELVIS – Benign neoplasm: Renal pelvis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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