rectum cancer: A primary or metastatic malignant neoplasm that affects the rectum. Representative examples include carcinoma, lymphoma, and sarcoma.
Benign neoplasm: Rectum, anus and anal canal
DOID EFO Endpoint Browser PheWeb
CD2_BENIGN_RECTUM_ANAL
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
7152 |
6. Filter based on genotype QC (FinnGen only) |
6913 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Rectum, anus and anal canal
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasms
- Benign neoplasms
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 46435 | 23043 | 23086 |
| Only index persons | 41450 | 21048 | 20402 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.65 | 0.66 | 0.65 |
| Only index persons | 0.78 | 0.77 | 0.78 |
| Median age at first event (years) | |||
| Whole population | 65.74 | 65.69 | 65.75 |
| Only index persons | 65.19 | 65.09 | 65.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 6913 | 3287 | 3626 |
| Unadjusted period prevalence (%) | 1.57 | 1.29 | 1.82 |
| Median age at first event (years) | 65.16 | 63.46 | 66.69 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_RECTUM_ANAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_RECTUM_ANAL | 1.132 [1.04, 1.23] | 0.005 |
| Birth year | 0.996 [0.99, 1.0] | 0.264 |
During the follow-up period (1.1.1998 — 31.12.2019), 3757 out of 17553 females with CD2_BENIGN_RECTUM_ANAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_RECTUM_ANAL | 1.235 [1.13, 1.35] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 4969 out of 17500 males with CD2_BENIGN_RECTUM_ANAL died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_RECTUM_ANAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.226% |
| 5 | 0.703% | 1.476% |
| 10 | 1.868% | 3.671% |
| 15 | 3.512% | 6.876% |
| 20 | 5.84% | 11.146% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_RECTUM_ANAL – Benign neoplasm: Rectum, anus and anal canal
GWS hits: 5
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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