anal neoplasm: A benign or malignant neoplasm that affects the anal canal or anal margin. Representative examples of benign neoplasms include squamous papilloma and papillary hidradenoma. Representative examples of malignant neoplasms include carcinoma, lymphoma, and melanoma.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
895 |
4. Check minimum number of eventsNone |
895 |
5. Include endpointsNone |
895 |
6. Filter based on genotype QC (FinnGen only) |
860 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D12
Name in latin
Neoplasma benignum ani
Similar endpoints
↥List of similar endpoints to
Benign neoplasm: Anus and anal canal
based on the number of shared cases.
Similar with more cases:
- Benign neoplasm: Anus and anal canal
- Benign neoplasm: Rectum, anus and anal canal
- Benign neoplasm: Rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
- Benign neoplasm of colon, rectum, anus and anal canal
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6775 | 3595 | 3140 |
| Only index persons | 6211 | 3389 | 2822 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.09 |
| Only index persons | 0.12 | 0.12 | 0.11 |
| Median age at first event (years) | |||
| Whole population | 65.19 | 64.63 | 65.80 |
| Only index persons | 64.31 | 63.88 | 64.84 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 860 | 439 | 421 |
| Unadjusted period prevalence (%) | 0.19 | 0.17 | 0.21 |
| Median age at first event (years) | 63.44 | 60.74 | 66.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint CD2_BENIGN_ANUS_ANAL_CANAL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ANUS_ANAL_CANAL | 1.11 [0.99, 1.24] | 0.066 |
| Birth year | 0.998 [0.99, 1.01] | 0.643 |
During the follow-up period (1.1.1998 — 31.12.2019), 811 out of 3244 females with CD2_BENIGN_ANUS_ANAL_CANAL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| CD2_BENIGN_ANUS_ANAL_CANAL | 1.233 [1.1, 1.39] | < 0.001 |
| Birth year | 0.991 [0.98, 1.0] | 0.046 |
During the follow-up period (1.1.1998 — 31.12.2019), 997 out of 2848 males with CD2_BENIGN_ANUS_ANAL_CANAL died.
Mortality risk
Mortality risk for people of age
years, who have CD2_BENIGN_ANUS_ANAL_CANAL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | 0.274% |
| 5 | 0.735% | 1.418% |
| 10 | 1.683% | 3.814% |
| 15 | 3.423% | 7.36% |
| 20 | 6.062% | 12.725% |
Relationships between endpoints
↥Index endpoint: CD2_BENIGN_ANUS_ANAL_CANAL – Benign neoplasm: Anus and anal canal
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data