No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleNone |
- |
2. Check conditions
|
- |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpoints |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
C3_CANCER, C3_CANCER_WIDE
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF9
Similar endpoints
↥List of similar endpoints to
Brain glioblastoma and astrocytoma
based on the number of shared cases.
Similar with more cases:
- Brain glioblastoma and astrocytoma
- Malignant neoplasm of brain
- Malignant neoplasm of brain
- Malignant neoplasm of eye, brain and central nervous system
- Malignant neoplasm of eye, brain and central nervous system
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5422 | 2291 | 3041 |
| Only index persons | 2896 | 1237 | 1659 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.07 | 0.08 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 61.34 | 62.28 | 60.49 |
| Only index persons | 62.94 | 64.06 | 62.10 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 508 | 211 | 297 |
| Unadjusted period prevalence (%) | 0.12 | 0.08 | 0.15 |
| Median age at first event (years) | 62.12 | 60.82 | 63.05 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint C3_GBM_ASTROCYTOMA_EXALLC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_GBM_ASTROCYTOMA_EXALLC | 79.044 [41.81, 149.44] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.113 |
During the follow-up period (1.1.1998 — 31.12.2019), 1349 out of 1591 females with C3_GBM_ASTROCYTOMA_EXALLC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| C3_GBM_ASTROCYTOMA_EXALLC | 49.754 [27.45, 90.18] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.11 |
During the follow-up period (1.1.1998 — 31.12.2019), 1899 out of 2199 males with C3_GBM_ASTROCYTOMA_EXALLC died.
Mortality risk
Mortality risk for people of age
years, who have C3_GBM_ASTROCYTOMA_EXALLC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 8.171% | 7.913% |
| 5 | 33.074% | 44.877% |
| 10 | 62.786% | 79.58% |
| 15 | 85.538% | > 95% |
| 20 | > 95% | > 95% |
Relationships between endpoints
↥Index endpoint: C3_GBM_ASTROCYTOMA_EXALLC – Brain glioblastoma and astrocytoma
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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