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Brain astrocytoma

Endpoint Browser PheWeb

C3_ASTROCYTOMA_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_ASTROCYTOMA
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9400
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_ASTROCYTOMA

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1059 479 568
Only index persons 639 300 339
Unadjusted period prevalence (%)
Whole population 0.01 0.01 0.02
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 40.69 41.09 39.84
Only index persons 39.51 40.82 38.35

-FinnGen-

Key figures

All Female Male
Number of individuals 130 63 67
Unadjusted period prevalence (%) 0.03 0.02 0.03
Median age at first event (years) 39.72 38.49 40.87

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_ASTROCYTOMA_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_ASTROCYTOMA_EXALLC 32.291 [19.19, 54.35] < 0.001
Birth year 0.996 [0.99, 1.0] 0.3

During the follow-up period (1.1.1998 — 31.12.2019), 176 out of 298 females with C3_ASTROCYTOMA_EXALLC died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have C3_ASTROCYTOMA_EXALLC.

N-year risk Females Males
1 3.114% No data
5 16.005% No data
10 38.696% No data
15 62.104% No data
20 80.318% No data

Relationships between endpoints

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Index endpoint: C3_ASTROCYTOMA_EXALLC – Brain astrocytoma

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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