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Malignant neoplasm of brain

Endpoint Browser PheWeb

C3_BRAIN_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF9

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 15808 6982 8473
Only index persons 6827 3095 3732
Unadjusted period prevalence (%)
Whole population 0.22 0.20 0.24
Only index persons 0.13 0.11 0.14
Median age at first event (years)
Whole population 56.62 57.61 55.68
Only index persons 58.38 59.43 57.52

-FinnGen-

Key figures

All Female Male
Number of individuals 1070 465 605
Unadjusted period prevalence (%) 0.25 0.18 0.30
Median age at first event (years) 57.51 53.78 60.38

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint C3_BRAIN_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_BRAIN_EXALLC 47.224 [29.25, 76.24] < 0.001
Birth year 0.995 [0.99, 1.0] 0.276

During the follow-up period (1.1.1998 — 31.12.2019), 2608 out of 3380 females with C3_BRAIN_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_BRAIN_EXALLC 31.318 [20.76, 47.25] < 0.001
Birth year 0.989 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 3244 out of 4201 males with C3_BRAIN_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_BRAIN_EXALLC.

N-year risk Females Males
1 4.519% 5.068%
5 22.148% 29.859%
10 47.463% 59.176%
15 71.442% 83.943%
20 90.621% > 95%

Relationships between endpoints

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Index endpoint: C3_BRAIN_EXALLC – Malignant neoplasm of brain

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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