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Brain glioblastoma

Endpoint Browser PheWeb

C3_GBM_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

None

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2. Check conditions

  • HLP_C3_GBM
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3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Cause of death: ICD-10 — C71
  • Cause of death: ICD-9 — 191
  • Cause of death: ICD-8 — 191
  • Cancer registry: Topography ICD-O-3 — C71
  • Cancer registry: Morphology ICD-O-3 — 9440
  • Cancer registry: Behaviour codes — 3

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Control exclude C3_CANCER, C3_CANCER_WIDE
Control conditions not HLP_C3_GBM

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF8

Case counts by codes

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FinnGen case counts by registry codes:

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No upset table: script not run.

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4363 1812 2473
Only index persons 2257 937 1320
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.07
Only index persons 0.04 0.03 0.05
Median age at first event (years)
Whole population 63.71 65.05 62.64
Only index persons 65.60 66.91 64.67

-FinnGen-

Key figures

All Female Male
Number of individuals 378 148 230
Unadjusted period prevalence (%) 0.09 0.06 0.12
Median age at first event (years) 66.05 66.08 66.03

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint C3_GBM_EXALLC and mortality.

Females

Parameter HR [95% CI] p-value
C3_GBM_EXALLC 104.074 [43.35, 249.86] < 0.001
Birth year 0.994 [0.99, 1.0] 0.139

During the follow-up period (1.1.1998 — 31.12.2019), 1173 out of 1293 females with C3_GBM_EXALLC died.

Males

Parameter HR [95% CI] p-value
C3_GBM_EXALLC 61.277 [28.86, 130.1] < 0.001
Birth year 0.988 [0.98, 1.0] 0.011

During the follow-up period (1.1.1998 — 31.12.2019), 1682 out of 1844 males with C3_GBM_EXALLC died.

Mortality risk

Mortality risk for people of age

years, who have C3_GBM_EXALLC.

N-year risk Females Males
1 8.252% 8.562%
5 40.604% 46.485%
10 74.524% 80.512%
15 92.633% > 95%
20 > 95% > 95%

Relationships between endpoints

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Index endpoint: C3_GBM_EXALLC – Brain glioblastoma

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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