No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
767 |
6. Filter based on genotype QC (FinnGen only) |
748 |
Control definitions (FinnGen only)
Control exclude
RHEUMA_ENDPOINTS
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Other specific arthropathies
based on the number of shared cases.
Similar with more cases:
- Polyarthropathies
- Finngen Rheumatological endpoints
- Arthropathies
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5330 | 2986 | 2302 |
| Only index persons | 4747 | 2725 | 2022 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.06 |
| Only index persons | 0.09 | 0.10 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 47.23 | 48.64 | 45.31 |
| Only index persons | 45.54 | 47.24 | 43.26 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 748 | 459 | 289 |
| Unadjusted period prevalence (%) | 0.17 | 0.18 | 0.15 |
| Median age at first event (years) | 48.00 | 46.80 | 49.90 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint ARTHRO_SPEC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTHRO_SPEC | 1.041 [0.88, 1.23] | 0.631 |
| Birth year | 0.997 [0.99, 1.01] | 0.483 |
During the follow-up period (1.1.1998 — 31.12.2019), 205 out of 1773 females with ARTHRO_SPEC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| ARTHRO_SPEC | 1.271 [1.08, 1.5] | 0.005 |
| Birth year | 0.989 [0.98, 1.0] | 0.031 |
During the follow-up period (1.1.1998 — 31.12.2019), 220 out of 1252 males with ARTHRO_SPEC died.
Mortality risk
Mortality risk for people of age
years, who have ARTHRO_SPEC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.123% | 0.28% |
| 5 | 0.608% | 1.685% |
| 10 | 1.514% | 4.008% |
| 15 | 3.05% | 7.209% |
| 20 | 5.688% | 12.403% |
Relationships between endpoints
↥Index endpoint: ARTHRO_SPEC – Other specific arthropathies
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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