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Sequelae of infectious and parasitic diseases

EFO MESH Endpoint Browser PheWeb

AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B90-B94
  • Hospital discharge: ICD-9 — 13[7-9]
  • Hospital discharge: ICD-8 — 019|044|066
  • Cause of death: ICD-10 — B90-B94
  • Cause of death: ICD-9 — 13[7-9]
  • Cause of death: ICD-8 — 019|044|066

2 out of 7 registries used, show all original rules.

1032

4. Check minimum number of events

None

1032

5. Include endpoints

2992

6. Filter based on genotype QC (FinnGen only)

2900

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 38037 16544 20739
Only index persons 26574 12375 14199
Unadjusted period prevalence (%)
Whole population 0.54 0.47 0.58
Only index persons 0.50 0.45 0.54
Median age at first event (years)
Whole population 38.55 41.13 35.62
Only index persons 23.03 26.29 20.18

-FinnGen-

Key figures

All Female Male
Number of individuals 2900 1384 1516
Unadjusted period prevalence (%) 0.66 0.54 0.76
Median age at first event (years) 23.70 19.46 27.57

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES 1.847 [1.66, 2.06] < 0.001
Birth year 0.993 [0.98, 1.0] 0.14

During the follow-up period (1.1.1998 — 31.12.2019), 1440 out of 2917 females with AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES died.

Males

Parameter HR [95% CI] p-value
AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES 2.058 [1.82, 2.33] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 2077 out of 3401 males with AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES.

N-year risk Females Males
1 0.149% 0.359%
5 0.929% 2.127%
10 2.57% 5.136%
15 4.969% 10.246%
20 8.474% 17.367%

Relationships between endpoints

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Index endpoint: AB1_SEQULEAE_OF_INFECTIONS_AND_PARASITES – Sequelae of infectious and parasitic diseases

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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