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Sequelae of other and unspecified infectious and parasitic diseases

EFO Endpoint Browser PheWeb

AB1_SEQULAE_INF_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B94
  • Hospital discharge: ICD-9 — 139
  • Hospital discharge: ICD-8 — 066|079|074
  • Cause of death: ICD-10 — B94
  • Cause of death: ICD-9 — 139
  • Cause of death: ICD-8 — 066|079|074

2 out of 7 registries used, show all original rules.

2049

4. Check minimum number of events

None

2049

5. Include endpoints

None

2049

6. Filter based on genotype QC (FinnGen only)

2002

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 21962 9845 11952
Only index persons 18321 8154 10167
Unadjusted period prevalence (%)
Whole population 0.31 0.28 0.33
Only index persons 0.35 0.30 0.39
Median age at first event (years)
Whole population 14.15 14.25 13.58
Only index persons 10.07 10.00 10.12

-FinnGen-

Key figures

All Female Male
Number of individuals 2002 1043 959
Unadjusted period prevalence (%) 0.44 0.41 0.48
Median age at first event (years) 14.29 10.48 18.44

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_SEQULAE_INF_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEQULAE_INF_NOS 2.439 [1.53, 3.88] < 0.001
Birth year 0.998 [0.99, 1.01] 0.581

During the follow-up period (1.1.1998 — 31.12.2019), 68 out of 237 females with AB1_SEQULAE_INF_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_SEQULAE_INF_NOS 2.677 [1.74, 4.12] < 0.001
Birth year 0.989 [0.98, 1.0] 0.062

During the follow-up period (1.1.1998 — 31.12.2019), 101 out of 274 males with AB1_SEQULAE_INF_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEQULAE_INF_NOS.

N-year risk Females Males
1 0.249% 0.647%
5 1.448% 3.526%
10 3.887% 8.412%
15 7.002% 15.39%
20 12.447% 24.513%

Relationships between endpoints

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Index endpoint: AB1_SEQULAE_INF_NOS – Sequelae of other and unspecified infectious and parasitic diseases

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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