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Sequelae of poliomyelitis

EFO Endpoint Browser PheWeb

AB1_SEQULAE_POLIO

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B91
  • Hospital discharge: ICD-9 — 138
  • Hospital discharge: ICD-8 — 04[4]
  • Cause of death: ICD-10 — B91
  • Cause of death: ICD-9 — 138
  • Cause of death: ICD-8 — 04[4]

2 out of 7 registries used, show all original rules.

252

4. Check minimum number of events

None

252

5. Include endpoints

None

252

6. Filter based on genotype QC (FinnGen only)

237

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3267 1689 1520
Only index persons 2365 1316 1049
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.04 0.05 0.04
Median age at first event (years)
Whole population 58.93 58.69 59.11
Only index persons 57.84 57.31 58.50

-FinnGen-

Key figures

All Female Male
Number of individuals 237 108 129
Unadjusted period prevalence (%) 0.05 0.04 0.06
Median age at first event (years) 59.49 57.85 60.86

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

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Association

Association between endpoint AB1_SEQULAE_POLIO and mortality.

Females

Parameter HR [95% CI] p-value
AB1_SEQULAE_POLIO 1.391 [1.15, 1.68] < 0.001
Birth year 0.995 [0.99, 1.0] 0.261

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 652 females with AB1_SEQULAE_POLIO died.

Males

Parameter HR [95% CI] p-value
AB1_SEQULAE_POLIO 1.694 [1.4, 2.05] < 0.001
Birth year 0.988 [0.98, 1.0] 0.01

During the follow-up period (1.1.1998 — 31.12.2019), 273 out of 623 males with AB1_SEQULAE_POLIO died.

Mortality risk

Mortality risk for people of age

years, who have AB1_SEQULAE_POLIO.

N-year risk Females Males
1 0.116% 0.295%
5 0.895% 1.986%
10 2.244% 4.869%
15 4.346% 9.197%
20 7.669% 15.654%

Relationships between endpoints

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Index endpoint: AB1_SEQULAE_POLIO – Sequelae of poliomyelitis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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