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Other viral diseases

DOID EFO Endpoint Browser PheWeb

AB1_OTHER_VIRAL

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B25-B34
  • Hospital discharge: ICD-9 — 078[5-5]|078[7-8]
  • Hospital discharge: ICD-8 — 075|079[2-9]
  • Cause of death: ICD-10 — B25-B34
  • Cause of death: ICD-9 — 078[5-5]|078[7-8]
  • Cause of death: ICD-8 — 075|079[2-9]

2 out of 7 registries used, show all original rules.

9779

4. Check minimum number of events

None

9779

5. Include endpoints

13178

6. Filter based on genotype QC (FinnGen only)

12694

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 173250 83734 88943
Only index persons 145681 71009 74672
Unadjusted period prevalence (%)
Whole population 2.44 2.40 2.49
Only index persons 2.73 2.61 2.85
Median age at first event (years)
Whole population 16.67 16.78 16.42
Only index persons 17.83 17.79 17.88

-FinnGen-

Key figures

All Female Male
Number of individuals 12694 7392 5302
Unadjusted period prevalence (%) 2.80 2.90 2.66
Median age at first event (years) 22.40 21.51 23.64

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_OTHER_VIRAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_VIRAL 1.969 [1.68, 2.3] < 0.001
Birth year 0.996 [0.99, 1.0] 0.36

During the follow-up period (1.1.1998 — 31.12.2019), 2782 out of 52417 females with AB1_OTHER_VIRAL died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_VIRAL 1.946 [1.65, 2.29] < 0.001
Birth year 0.988 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 2997 out of 51962 males with AB1_OTHER_VIRAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_VIRAL.

N-year risk Females Males
1 0.173% 0.401%
5 1.026% 2.412%
10 2.718% 6.107%
15 5.171% 10.796%
20 9.72% 17.64%

Relationships between endpoints

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Index endpoint: AB1_OTHER_VIRAL – Other viral diseases

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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