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Other viral diseases, not elsewhere classified

EFO Endpoint Browser PheWeb

AB1_VIRAL_NOS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B33, B34
  • Hospital discharge: ICD-9 — 07[8]
  • Hospital discharge: ICD-8 — 07[6|9]
  • Cause of death: ICD-10 — B33, B34
  • Cause of death: ICD-9 — 07[8]
  • Cause of death: ICD-8 — 07[6|9]

2 out of 7 registries used, show all original rules.

7663

4. Check minimum number of events

None

7663

5. Include endpoints

None

7663

6. Filter based on genotype QC (FinnGen only)

7371

Control definitions (FinnGen only)

Control exclude AB1_OTHER_VIRAL

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 110387 53139 56838
Only index persons 85890 41690 44200
Unadjusted period prevalence (%)
Whole population 1.55 1.52 1.59
Only index persons 1.61 1.53 1.69
Median age at first event (years)
Whole population 10.94 11.81 9.89
Only index persons 15.70 16.95 14.52

-FinnGen-

Key figures

All Female Male
Number of individuals 7371 4148 3223
Unadjusted period prevalence (%) 1.62 1.63 1.62
Median age at first event (years) 27.17 25.36 29.51

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_VIRAL_NOS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_NOS 1.889 [1.6, 2.23] < 0.001
Birth year 0.995 [0.99, 1.0] 0.222

During the follow-up period (1.1.1998 — 31.12.2019), 2104 out of 32170 females with AB1_VIRAL_NOS died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_NOS 1.949 [1.59, 2.39] < 0.001
Birth year 0.982 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 2159 out of 33629 males with AB1_VIRAL_NOS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_NOS.

N-year risk Females Males
1 0.178% 0.268%
5 1.02% 1.834%
10 2.612% 4.638%
15 5.267% 8.89%
20 9.43% 14.819%

Relationships between endpoints

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Index endpoint: AB1_VIRAL_NOS – Other viral diseases, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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