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Bacterial, viral and other infectious agents

EFO MESH Endpoint Browser PheWeb

AB1_BACT_BIR_OTHER_INF_AGENTS

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — B9[5-7]
  • Hospital discharge: ICD-9 — 07[9-9]|034[0-0]
  • Hospital discharge: ICD-8 — 034[0-0]|074|078
  • Cause of death: ICD-10 — B9[5-7]
  • Cause of death: ICD-9 — 07[9-9]|034[0-0]
  • Cause of death: ICD-8 — 034[0-0]|074|078

2 out of 7 registries used, show all original rules.

3299

4. Check minimum number of events

None

3299

5. Include endpoints

3299

6. Filter based on genotype QC (FinnGen only)

3171

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy 2
First used in FinnGen datafreeze DF2

Similar endpoints

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Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 36180 13424 22611
Only index persons 31070 11109 19961
Unadjusted period prevalence (%)
Whole population 0.54 0.38 0.63
Only index persons 0.64 0.41 0.76
Median age at first event (years)
Whole population 20.92 22.23 19.95
Only index persons 20.34 21.08 19.93

-FinnGen-

Key figures

All Female Male
Number of individuals 3171 1368 1803
Unadjusted period prevalence (%) 0.75 0.54 0.91
Median age at first event (years) 22.05 24.13 20.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint AB1_BACT_BIR_OTHER_INF_AGENTS and mortality.

Females

Parameter HR [95% CI] p-value
AB1_BACT_BIR_OTHER_INF_AGENTS 1.888 [1.63, 2.18] < 0.001
Birth year 0.997 [0.99, 1.0] 0.416

During the follow-up period (1.1.1998 — 31.12.2019), 912 out of 5197 females with AB1_BACT_BIR_OTHER_INF_AGENTS died.

Males

Parameter HR [95% CI] p-value
AB1_BACT_BIR_OTHER_INF_AGENTS 2.315 [1.97, 2.72] < 0.001
Birth year 0.988 [0.98, 1.0] 0.012

During the follow-up period (1.1.1998 — 31.12.2019), 852 out of 3876 males with AB1_BACT_BIR_OTHER_INF_AGENTS died.

Mortality risk

Mortality risk for people of age

years, who have AB1_BACT_BIR_OTHER_INF_AGENTS.

N-year risk Females Males
1 0.198% 0.503%
5 0.991% 2.864%
10 2.58% 7.067%
15 5.194% 12.643%
20 9.827% 21.262%

Relationships between endpoints

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Index endpoint: AB1_BACT_BIR_OTHER_INF_AGENTS – Bacterial, viral and other infectious agents

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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