Other bacterial agents as the cause of diseases classified to other chapters

AB1_OTHER_BACT_INOTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B96
  • Cause of death: ICD-10 B96

2 out of 7 registries used, show all original rules.

319

4. Check minimum number of events

None

319

5. Include endpoints

None

319

6. Filter based on genotype QC (FinnGen only)

311

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3169 1962 1175
Only index persons 2334 1415 919
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.03
Only index persons 0.05 0.05 0.04
Median age at first event (years)
Whole population 62.07 63.04 60.18
Only index persons 53.67 53.02 54.69

-FinnGen-

Key figures

All Female Male
Number of individuals 311 192 119
Unadjusted period prevalence (%) 0.07 0.08 0.06
Median age at first event (years) 57.56 54.21 62.97

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_BACT_INOTHER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.026 [1.66, 2.48] < 0.001
Birth year 0.995 [0.99, 1.0] 0.22

During the follow-up period (1.1.1998 — 31.12.2019), 562 out of 1325 females with AB1_OTHER_BACT_INOTHER died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_BACT_INOTHER 2.755 [2.11, 3.59] < 0.001
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 352 out of 852 males with AB1_OTHER_BACT_INOTHER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_BACT_INOTHER.

N-year risk Females Males
1 0.208% 0.509%
5 1.246% 2.961%
10 3.141% 7.155%
15 5.804% 13.554%
20 10.293% 21.955%

Relationships between endpoints

Index endpoint: AB1_OTHER_BACT_INOTHER – Other bacterial agents as the cause of diseases classified to other chapters

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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