Viral agents as the cause of diseases classified to other chapters

AB1_VIRAL_INOTHER

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 B97
  • Cause of death: ICD-10 B97

2 out of 7 registries used, show all original rules.

683

4. Check minimum number of events

None

683

5. Include endpoints

None

683

6. Filter based on genotype QC (FinnGen only)

645

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5957 3647 2291
Only index persons 4638 3028 1610
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.06
Only index persons 0.09 0.11 0.06
Median age at first event (years)
Whole population 33.79 33.38 34.36
Only index persons 42.90 39.38 49.53

-FinnGen-

Key figures

All Female Male
Number of individuals 645 387 258
Unadjusted period prevalence (%) 0.14 0.15 0.13
Median age at first event (years) 48.08 41.57 57.85

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint AB1_VIRAL_INOTHER and mortality.

Females

Parameter HR [95% CI] p-value
AB1_VIRAL_INOTHER 1.297 [1.03, 1.63] 0.027
Birth year 0.997 [0.99, 1.01] 0.466

During the follow-up period (1.1.1998 — 31.12.2019), 179 out of 3038 females with AB1_VIRAL_INOTHER died.

Males

Parameter HR [95% CI] p-value
AB1_VIRAL_INOTHER 1.371 [1.09, 1.73] 0.008
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 200 out of 1909 males with AB1_VIRAL_INOTHER died.

Mortality risk

Mortality risk for people of age

years, who have AB1_VIRAL_INOTHER.

N-year risk Females Males
1 0.12% 0.312%
5 0.834% 1.677%
10 2.084% 3.887%
15 3.811% 7.782%
20 6.855% 12.966%

Relationships between endpoints

Index endpoint: AB1_VIRAL_INOTHER – Viral agents as the cause of diseases classified to other chapters

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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