ascorbic acid deficiency: A condition due to a dietary deficiency of ascorbic acid (vitamin C), characterized by malaise, lethargy, and weakness. As the disease progresses, joints, muscles, and subcutaneous tissues may become the sites of hemorrhage. Ascorbic acid deficiency frequently develops into scurvy in young children fed unsupplemented cow's milk exclusively during their first year. It develops also commonly in chronic alcoholism. (Cecil Textbook of Medicine, 19th ed, p1177)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
1703 |
6. Filter based on genotype QC (FinnGen only) |
1617 |
Control definitions (FinnGen only)
Control exclude
E4_NUTRIDEF
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Vitamin deficiency
based on the number of shared cases.
Similar with more cases:
- Vitamin deficiency
- Other nutritional deficiencies
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 15478 | 8311 | 7025 |
| Only index persons | 12975 | 7087 | 5888 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.22 | 0.24 | 0.20 |
| Only index persons | 0.24 | 0.26 | 0.22 |
| Median age at first event (years) | |||
| Whole population | 60.22 | 60.18 | 60.20 |
| Only index persons | 58.19 | 57.69 | 58.80 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1617 | 942 | 675 |
| Unadjusted period prevalence (%) | 0.36 | 0.37 | 0.34 |
| Median age at first event (years) | 56.28 | 51.50 | 62.94 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint VIT_DEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VIT_DEF | 1.78 [1.58, 2.01] | < 0.001 |
| Birth year | 0.996 [0.99, 1.0] | 0.37 |
During the follow-up period (1.1.1998 — 31.12.2019), 1968 out of 5963 females with VIT_DEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| VIT_DEF | 2.466 [2.12, 2.87] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1987 out of 4814 males with VIT_DEF died.
Mortality risk
Mortality risk for people of age
years, who have VIT_DEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.159% | 0.53% |
| 5 | 1.056% | 2.998% |
| 10 | 2.595% | 6.818% |
| 15 | 5.044% | 12.608% |
| 20 | 8.946% | 20.444% |
Relationships between endpoints
↥Index endpoint: VIT_DEF – Vitamin deficiency
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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