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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Deficiency of other/unspecified vitamins

MESH Endpoint Browser

E4_VIT_NAS_DEF

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E56.8, E56.9
  • Hospital discharge: ICD-9 — 269[1-2]
  • Hospital discharge: ICD-8 — 266[8-9]
  • Hospital discharge: excluded ICD-8 — 26688
  • Cause of death: ICD-10 — E56.8, E56.9
  • Cause of death: ICD-9 — 269[1-2]
  • Cause of death: ICD-8 — 266[8-9]
  • Cause of death: excluded ICD-8 — 26688

2 out of 7 registries used, show all original rules.

48

4. Check minimum number of events

None

48

5. Include endpoints

None

48

6. Filter based on genotype QC (FinnGen only)

46

Control definitions (FinnGen only)

Control exclude E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 344 188 154
Only index persons 302 165 137
Unadjusted period prevalence (%)
Whole population 0.00 0.01 0.00
Only index persons 0.01 0.01 0.01
Median age at first event (years)
Whole population 60.93 59.56 62.55
Only index persons 61.44 59.66 63.58

-FinnGen-

Key figures

All Female Male
Number of individuals 46 26 20
Unadjusted period prevalence (%) 0.01 0.01 0.01
Median age at first event (years) 62.12 59.27 65.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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Association

Association between endpoint E4_VIT_NAS_DEF and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
E4_VIT_NAS_DEF 1.706 [0.86, 3.38] 0.125
Birth year 0.987 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 52 out of 118 males with E4_VIT_NAS_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_NAS_DEF.

N-year risk Females Males
1 No data 0.391%
5 No data 1.968%
10 No data 5.044%
15 No data 9.336%
20 No data 15.5%

Relationships between endpoints

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Index endpoint: E4_VIT_NAS_DEF – Deficiency of other/unspecified vitamins

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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