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Deficiency of other B group vitamins

DOID EFO Endpoint Browser PheWeb

E4_VIT_B_DEF

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E53
  • Hospital discharge: ICD-9 — 266
  • Hospital discharge: ICD-8 — 264
  • Cause of death: ICD-10 — E53
  • Cause of death: ICD-9 — 266
  • Cause of death: ICD-8 — 264
  • KELA reimbursements: KELA codes — ANY
  • KELA reimbursements: ICD-10 — E53.8

3 out of 7 registries used, show all original rules.

721

4. Check minimum number of events

None

721

5. Include endpoints

None

721

6. Filter based on genotype QC (FinnGen only)

695

Control definitions (FinnGen only)

Control exclude E4_NUTRIDEF

Extra metadata

Level in the ICD hierarchy 4
First used in FinnGen datafreeze DF2
Parent code in ICD-10 E50-E64
Name in latin Deficientia aliorum vitaminorum B

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4877 2712 2110
Only index persons 3881 2214 1667
Unadjusted period prevalence (%)
Whole population 0.07 0.08 0.06
Only index persons 0.07 0.08 0.06
Median age at first event (years)
Whole population 73.31 74.06 72.33
Only index persons 72.05 72.65 71.25

-FinnGen-

Key figures

All Female Male
Number of individuals 695 396 299
Unadjusted period prevalence (%) 0.15 0.16 0.15
Median age at first event (years) 61.78 56.38 68.93

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint E4_VIT_B_DEF and mortality.

Females

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.558 [1.34, 1.81] < 0.001
Birth year 0.995 [0.99, 1.0] 0.248

During the follow-up period (1.1.1998 — 31.12.2019), 919 out of 2076 females with E4_VIT_B_DEF died.

Males

Parameter HR [95% CI] p-value
E4_VIT_B_DEF 1.736 [1.45, 2.08] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 800 out of 1606 males with E4_VIT_B_DEF died.

Mortality risk

Mortality risk for people of age

years, who have E4_VIT_B_DEF.

N-year risk Females Males
1 0.131% 0.299%
5 0.919% 1.861%
10 2.566% 4.57%
15 4.72% 8.204%
20 8.144% 13.297%

Relationships between endpoints

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Index endpoint: E4_VIT_B_DEF – Deficiency of other B group vitamins

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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