adult-onset Still's disease: adult-onset Still disease (AOSD) is a rare inflammatory multisystem disorder characterized clinically by fever of unknown origin, arthralgia or arthritis, hyperleucocytosis, and typical skin rash.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
114 |
4. Check minimum number of eventsNone |
114 |
5. Include endpointsNone |
114 |
6. Filter based on genotype QC (FinnGen only) |
111 |
Control definitions (FinnGen only)
Control exclude
ILD_SYST_AUTO_DISEASES
Extra metadata
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Rheumatoid lung disease
based on the number of shared cases.
Similar with more cases:
- Seropositive rheumatoid arthritis
- Polyarthropathies
- Autoimmune diseases related-to ILD
- Finngen Rheumatological endpoints
- Arthropathies
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 998 | 519 | 473 |
| Only index persons | 705 | 370 | 335 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.01 | 0.01 | 0.01 |
| Only index persons | 0.01 | 0.01 | 0.01 |
| Median age at first event (years) | |||
| Whole population | 70.83 | 71.81 | 69.83 |
| Only index persons | 70.05 | 70.59 | 69.45 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 111 | 48 | 63 |
| Unadjusted period prevalence (%) | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | 70.59 | 70.41 | 70.73 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
Mortality – FinRegistry
↥Association
Association between endpoint RHEUMAT_LUNG and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 4.335 [3.39, 5.55] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.19 |
During the follow-up period (1.1.1998 — 31.12.2019), 221 out of 379 females with RHEUMAT_LUNG died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| RHEUMAT_LUNG | 3.125 [2.41, 4.05] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 351 males with RHEUMAT_LUNG died.
Mortality risk
Mortality risk for people of age
years, who have RHEUMAT_LUNG.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.334% | 0.578% |
| 5 | 2.191% | 3.843% |
| 10 | 5.284% | 9.686% |
| 15 | 10.592% | 17.551% |
| 20 | 19.317% | 28.326% |
Relationships between endpoints
↥Index endpoint: RHEUMAT_LUNG – Rheumatoid lung disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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