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Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8

Endpoint Browser PheWeb

O15_ICP_WIDE_EXMORE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

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2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O26.6
  • Hospital discharge: ICD-9 — 6467
  • Hospital discharge: ICD-8 — 6390
  • Cause of death: ICD-10 — O26.6
  • Cause of death: ICD-9 — 6467
  • Cause of death: ICD-8 — 6390

2 out of 7 registries used, show all original rules.

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4. Check minimum number of events

None

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5. Include endpoints

None

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6. Filter based on genotype QC (FinnGen only)

None

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Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O26
Name in latin Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Case counts by codes

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FinnGen case counts by registry codes:

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Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23532 23532 -
Only index persons 23124 23124 -
Unadjusted period prevalence (%)
Whole population 0.67 0.67 -
Only index persons 0.85 0.85 -
Median age at first event (years)
Whole population - 29.44 -
Only index persons - 29.44 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3114 3114 -
Unadjusted period prevalence (%) 1.22 1.22 -
Median age at first event (years) 29.62 29.62 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

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Association

Association between endpoint O15_ICP_WIDE_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_WIDE_EXMORE 0.645 [0.51, 0.82] < 0.001
Birth year 0.994 [0.99, 1.0] 0.15

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE_EXMORE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_WIDE_EXMORE.

N-year risk Females Males
1 0.056% No data
5 0.347% No data
10 0.859% No data
15 1.645% No data
20 2.956% No data

Relationships between endpoints

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Index endpoint: O15_ICP_WIDE_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8

GWS hits: 28

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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