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Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8

EFO Endpoint Browser PheWeb

O15_ICP_WIDE

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — O26.6
  • Hospital discharge: ICD-9 — 6467
  • Hospital discharge: ICD-8 — 6390
  • Cause of death: ICD-10 — O26.6
  • Cause of death: ICD-9 — 6467
  • Cause of death: ICD-8 — 6390

2 out of 7 registries used, show all original rules.

3252

4. Check minimum number of events

None

3252

5. Include endpoints

None

3252

6. Filter based on genotype QC (FinnGen only)

3114

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF5
Parent code in ICD-10 O26
Name in latin Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 23532 23532 -
Only index persons 23124 23124 -
Unadjusted period prevalence (%)
Whole population 0.67 0.67 -
Only index persons 0.85 0.85 -
Median age at first event (years)
Whole population - 29.44 -
Only index persons - 29.44 -

-FinnGen-

Key figures

All Female Male
Number of individuals 3114 3114 -
Unadjusted period prevalence (%) 1.22 1.22 -
Median age at first event (years) 29.62 29.62 -

-FinRegistry-

Age distribution of first events

02030400k1k2k3k4k5k6k7k8k9k10k11kAgeIndividuals

-FinnGen-

Age distribution of first events

01020304050607080900.0k0.2k0.4k0.6k0.8k1.0k1.2k1.4kAgeIndividuals

-FinRegistry-

Year distribution of first events

1970197519801985199019952000200520102015202020220.0k0.5k1.0k1.5k2.0k2.5k3.0kYearIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023050100150200250300350400450YearIndividuals

-FinRegistry-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.0AgeProbability of first incidence (%)

-FinnGen-

Cumulative Incidence Function

01020304050607080901000.00.20.40.60.81.01.21.41.61.82.02.22.42.62.83.0AgeProbability of first incidence (%)

Mortality – FinRegistry

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Association

Association between endpoint O15_ICP_WIDE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_WIDE 0.645 [0.51, 0.82] < 0.001
Birth year 0.994 [0.99, 1.0] 0.15

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13316 females with O15_ICP_WIDE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_WIDE.

N-year risk Females Males
1 0.056% No data
5 0.347% No data
10 0.859% No data
15 1.645% No data
20 2.956% No data

Relationships between endpoints

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Index endpoint: O15_ICP_WIDE – Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8

GWS hits: 27

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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