No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
|
1. Apply sex-specific ruleonly females |
- |
2. Check conditionsNone |
|
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
- |
4. Check minimum number of eventsNone |
- |
5. Include endpointsNone |
- |
6. Filter based on genotype QC (FinnGen only)None |
- |
Control definitions (FinnGen only)
Control exclude
!(O15_DELIVERY, O15_DELIVERY_PROXY)
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Parent code in ICD-10
O26
Name in latin
Morbositates hepatis in graviditate, intra labores et/sive in puerperio
Similar endpoints
↥List of similar endpoints to
Intrahepatic Cholestasis of Pregnancy (ICP)
based on the number of shared cases.
Similar with more cases:
- Intrahepatic Cholestasis of Pregnancy (ICP)
- Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8
- Intrahepatic Cholestasis of Pregnancy (ICP) , incl. ICD-8
- Pregnancy, childbirth and the puerperium
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥FinnGen case counts by registry codes:
No upset plot: script not run.
No upset table: script not run.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 19565 | 19565 | - |
| Only index persons | 19357 | 19357 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.56 | 0.56 | - |
| Only index persons | 0.71 | 0.71 | - |
| Median age at first event (years) | |||
| Whole population | - | 29.97 | - |
| Only index persons | - | 29.97 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2554 | 2554 | - |
| Unadjusted period prevalence (%) | 1.00 | 1.00 | - |
| Median age at first event (years) | 30.48 | 30.48 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint O15_ICP_EXMORE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| O15_ICP_EXMORE | 0.646 [0.5, 0.83] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.437 |
During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13331 females with O15_ICP_EXMORE died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have O15_ICP_EXMORE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.056% | No data |
| 5 | 0.38% | No data |
| 10 | 1.081% | No data |
| 15 | 1.972% | No data |
| 20 | 3.48% | No data |
Relationships between endpoints
↥Index endpoint: O15_ICP_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP)
GWS hits: 21
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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