Intrahepatic Cholestasis of Pregnancy (ICP) 

O15_ICP_EXMORE

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O26.6
  • Hospital discharge: ICD-9 6467
  • Cause of death: ICD-10 O26.6
  • Cause of death: ICD-9 6467

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3
Parent code in ICD-10 O26
Name in latin Morbositates hepatis in graviditate, intra labores et/sive in puerperio

Case counts by codes

FinnGen case counts by registry codes:

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Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 19565 19565 -
Only index persons 19357 19357 -
Unadjusted period prevalence (%)
Whole population 0.56 0.56 -
Only index persons 0.71 0.71 -
Median age at first event (years)
Whole population - 29.97 -
Only index persons - 29.97 -

-FinnGen-

Key figures

All Female Male
Number of individuals 2554 2554 -
Unadjusted period prevalence (%) 1.00 1.00 -
Median age at first event (years) 30.48 30.48 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint O15_ICP_EXMORE and mortality.

Females

Parameter HR [95% CI] p-value
O15_ICP_EXMORE 0.646 [0.5, 0.83] < 0.001
Birth year 0.997 [0.99, 1.01] 0.437

During the follow-up period (1.1.1998 — 31.12.2019), 78 out of 13331 females with O15_ICP_EXMORE died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_ICP_EXMORE.

N-year risk Females Males
1 0.056% No data
5 0.38% No data
10 1.081% No data
15 1.972% No data
20 3.48% No data

Relationships between endpoints

Index endpoint: O15_ICP_EXMORE – Intrahepatic Cholestasis of Pregnancy (ICP) 

GWS hits: 21

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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