Other disorders of breast

N14_BREASTDISOTH

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

only females

265735

2. Check conditions

None

265735

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N64
  • Hospital discharge: ICD-9 611[2-9]
  • Hospital discharge: ICD-8 611[2-9]
  • Hospital discharge: excluded ICD-9 6117B
  • Cause of death: ICD-10 N64
  • Cause of death: ICD-9 611[2-9]
  • Cause of death: ICD-8 611[2-9]
  • Cause of death: excluded ICD-9 6117B

2 out of 7 registries used, show all original rules.

4611

4. Check minimum number of events

None

4611

5. Include endpoints

4649

6. Filter based on genotype QC (FinnGen only)

4440

Control definitions (FinnGen only)

Control exclude N14_BREAST

Extra metadata

Level in the ICD hierarchy 3
First used in FinnGen datafreeze DF2
Parent code in ICD-10 N60-N64
Name in latin Aliae morbositates mammae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 30304 30304 -
Only index persons 28891 28891 -
Unadjusted period prevalence (%)
Whole population 0.87 0.87 -
Only index persons 1.06 1.06 -
Median age at first event (years)
Whole population - 45.19 -
Only index persons - 44.88 -

-FinnGen-

Key figures

All Female Male
Number of individuals 4440 4440 -
Unadjusted period prevalence (%) 1.74 1.74 -
Median age at first event (years) 47.28 47.28 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint N14_BREASTDISOTH and mortality.

Females

Parameter HR [95% CI] p-value
N14_BREASTDISOTH 1.077 [0.97, 1.19] 0.158
Birth year 1.0 [0.99, 1.01] 0.995

During the follow-up period (1.1.1998 — 31.12.2019), 1651 out of 19347 females with N14_BREASTDISOTH died.

Males

No data

Mortality risk

Mortality risk for people of age

years, who have N14_BREASTDISOTH.

N-year risk Females Males
1 0.101% No data
5 0.608% No data
10 1.64% No data
15 3.322% No data
20 6.147% No data

Relationships between endpoints

Index endpoint: N14_BREASTDISOTH – Other disorders of breast

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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