breast disease: A disease involving the breast.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
18564 |
4. Check minimum number of eventsNone |
18564 |
5. Include endpoints |
21873 |
6. Filter based on genotype QC (FinnGen only) |
21033 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
Level in the ICD hierarchy
2
First used in FinnGen datafreeze
DF2
Disorders of breast
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 156798 | 156798 | - |
| Only index persons | 147543 | 147543 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 4.49 | 4.49 | - |
| Only index persons | 5.42 | 5.42 | - |
| Median age at first event (years) | |||
| Whole population | - | 45.73 | - |
| Only index persons | - | 45.26 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 21033 | 21033 | - |
| Unadjusted period prevalence (%) | 8.26 | 8.26 | - |
| Median age at first event (years) | 45.92 | 45.92 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_BREAST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_BREAST | 1.169 [1.07, 1.27] | < 0.001 |
| Birth year | 0.994 [0.99, 1.0] | 0.127 |
During the follow-up period (1.1.1998 — 31.12.2019), 9467 out of 101005 females with N14_BREAST died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_BREAST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.12% | No data |
| 5 | 0.659% | No data |
| 10 | 1.741% | No data |
| 15 | 3.125% | No data |
| 20 | 5.368% | No data |
Relationships between endpoints
↥Index endpoint: N14_BREAST – Disorders of breast
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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