mastitis: Inflammation of breast tissue during lactation or postpartum due to an obstructed duct or infection. Mastitis can also occur in non-breastfeeding women, and rarely in men.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleonly females |
265735 |
2. Check conditionsNone |
265735 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
2263 |
4. Check minimum number of eventsNone |
2263 |
5. Include endpointsNone |
2263 |
6. Filter based on genotype QC (FinnGen only) |
2167 |
Control definitions (FinnGen only)
Control exclude
N14_BREAST
Extra metadata
Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
N60-N64
Name in latin
Morbositates inflammatoriae mammae
Inflammatory disorders of breast
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 16636 | 16636 | - |
| Only index persons | 15813 | 15813 | - |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.48 | 0.48 | - |
| Only index persons | 0.58 | 0.58 | - |
| Median age at first event (years) | |||
| Whole population | - | 36.61 | - |
| Only index persons | - | 36.07 | - |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2167 | 2167 | - |
| Unadjusted period prevalence (%) | 0.85 | 0.85 | - |
| Median age at first event (years) | 37.81 | 37.81 | - |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint N14_INFLAMMBREAST and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| N14_INFLAMMBREAST | 1.845 [1.61, 2.11] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.539 |
During the follow-up period (1.1.1998 — 31.12.2019), 831 out of 11950 females with N14_INFLAMMBREAST died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have N14_INFLAMMBREAST.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.253% | No data |
| 5 | 1.24% | No data |
| 10 | 3.062% | No data |
| 15 | 5.57% | No data |
| 20 | 9.691% | No data |
Relationships between endpoints
↥Index endpoint: N14_INFLAMMBREAST – Inflammatory disorders of breast
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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