No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
473375 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
2298 |
6. Filter based on genotype QC (FinnGen only) |
2229 |
Control definitions (FinnGen only)
Control conditions
not CML
Extra metadata
First used in FinnGen datafreeze
DF2, additional
Myeloproliferative diseases (CML excluded)
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 17116 | 9105 | 7806 |
| Only index persons | 13283 | 7288 | 5995 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.24 | 0.26 | 0.22 |
| Only index persons | 0.25 | 0.27 | 0.23 |
| Median age at first event (years) | |||
| Whole population | 66.96 | 67.88 | 65.89 |
| Only index persons | 65.96 | 66.95 | 64.75 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 2229 | 1148 | 1081 |
| Unadjusted period prevalence (%) | 0.50 | 0.45 | 0.54 |
| Median age at first event (years) | 64.08 | 63.03 | 65.19 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MYELOPROF_NONCML and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYELOPROF_NONCML | 1.761 [1.59, 1.95] | < 0.001 |
| Birth year | 0.997 [0.99, 1.0] | 0.442 |
During the follow-up period (1.1.1998 — 31.12.2019), 2311 out of 6630 females with MYELOPROF_NONCML died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MYELOPROF_NONCML | 2.042 [1.82, 2.3] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 2138 out of 5583 males with MYELOPROF_NONCML died.
Mortality risk
Mortality risk for people of age
years, who have MYELOPROF_NONCML.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.148% | 0.447% |
| 5 | 0.997% | 2.13% |
| 10 | 2.64% | 5.732% |
| 15 | 4.798% | 10.796% |
| 20 | 8.698% | 18.321% |
Relationships between endpoints
↥Index endpoint: MYELOPROF_NONCML – Myeloproliferative diseases (CML excluded)
GWS hits: 18
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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