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This is a non-core endpoint: only basic statistics are computed.

See these related core endpoints for full statistics:

Myelofibrosis

DOID EFO Endpoint Browser

MYELOFIBROSIS

primary myelofibrosis: Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C94.5
  • Hospital discharge: ICD-9 — 2387A
  • Hospital discharge: ICD-8 — 209
  • Cause of death: ICD-10 — C94.5
  • Cause of death: ICD-9 — 2387A
  • Cause of death: ICD-8 — 209

2 out of 7 registries used, show all original rules.

23

4. Check minimum number of events

None

23

5. Include endpoints

None

23

6. Filter based on genotype QC (FinnGen only)

22

Control definitions (FinnGen only)

Control exclude MYELOPROF

Extra metadata

First used in FinnGen datafreeze DF2, additional

Case counts by codes

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FinnGen case counts by registry codes:

Not enough data for upset plot.

Full data table

Summary Statistics

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-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1166 538 578
Only index persons 125 73 52
Unadjusted period prevalence (%)
Whole population 0.02 0.02 0.02
Only index persons 0.00 0.00 0.00
Median age at first event (years)
Whole population 68.79 68.12 69.58
Only index persons 44.03 44.89 42.83

-FinnGen-

Key figures

All Female Male
Number of individuals 22 8 14
Unadjusted period prevalence (%) 0.01 0.00 0.01
Median age at first event (years) 52.65 36.59 61.84

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

No data

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

Mortality – FinRegistry

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Association

Association between endpoint MYELOFIBROSIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have MYELOFIBROSIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

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Index endpoint: MYELOFIBROSIS – Myelofibrosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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