ulcerative colitis: An inflammatory bowel disease involving the mucosal surface of the large intestine and rectum. It may present with an acute or slow onset and follows an intermittent or continuous course. Signs and symptoms include abdominal pain, diarrhea, fever, weight loss, and intestinal hemorrhage.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
5150 |
4. Check minimum number of eventsNone |
5150 |
5. Include endpointsNone |
5150 |
6. Filter based on genotype QC (FinnGen only) |
4976 |
Control definitions (FinnGen only)
Control exclude
K11_ENERCOLNONINF
Extra metadata
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
K51
Name in latin
Proctocolitis mucosalis
Similar endpoints
↥List of similar endpoints to
Mucosal proctocolitis
based on the number of shared cases.
Similar with more cases:
- Ulcerative colitis
- Inflammatory bowel disease
- Noninfective enteritis and colitis
- Autoimmune diseases related-to ILD
- Autoimmune diseases
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 30958 | 13651 | 17191 |
| Only index persons | 29989 | 13348 | 16641 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.44 | 0.39 | 0.48 |
| Only index persons | 0.57 | 0.49 | 0.64 |
| Median age at first event (years) | |||
| Whole population | 41.81 | 41.20 | 42.30 |
| Only index persons | 41.49 | 41.03 | 41.86 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 4976 | 2494 | 2482 |
| Unadjusted period prevalence (%) | 1.11 | 0.98 | 1.25 |
| Median age at first event (years) | 43.73 | 40.81 | 46.66 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint MUCOPROCT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MUCOPROCT | 1.349 [1.19, 1.53] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.093 |
During the follow-up period (1.1.1998 — 31.12.2019), 877 out of 12049 females with MUCOPROCT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| MUCOPROCT | 1.159 [1.05, 1.28] | 0.004 |
| Birth year | 0.988 [0.98, 1.0] | 0.015 |
During the follow-up period (1.1.1998 — 31.12.2019), 1600 out of 15193 males with MUCOPROCT died.
Mortality risk
Mortality risk for people of age
years, who have MUCOPROCT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.238% |
| 5 | 0.73% | 1.521% |
| 10 | 1.83% | 3.939% |
| 15 | 3.382% | 7.108% |
| 20 | 6.115% | 11.594% |
Relationships between endpoints
↥Index endpoint: MUCOPROCT – Mucosal proctocolitis
GWS hits: 33
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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