colitis: Inflammation of the colon.
Colitis, primary sclerosing, strict definition
DOID EFO Endpoint Browser PheWeb
K11_PSC_COLITIS_STRICT
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditions
|
2140 |
3. Check pre-conditions, main-only, mode, registry filtersNone 0 out of 7 registries used, show all original rules. |
0 |
4. Check minimum number of eventsNone |
0 |
5. Include endpoints |
360 |
6. Filter based on genotype QC (FinnGen only) |
354 |
Control definitions (FinnGen only)
Control conditions
not K11_CHOLANGI
Extra metadata
Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF3
Similar endpoints
↥List of similar endpoints to
Colitis, primary sclerosing, strict definition
based on the number of shared cases.
Similar with more cases:
- Colitis, primary sclerosing
- Cholangitis (primary sclerosing, PSC)
- Mucosal proctocolitis
- Ulcerative colitis
- Inflammatory bowel disease
Similar with less cases:
None
Case counts by codes
↥FinnGen case counts by registry codes:
No data for upset plot.
No data for upset table.
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1356 | 487 | 865 |
| Only index persons | 1293 | 469 | 824 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.01 | 0.02 |
| Only index persons | 0.03 | 0.02 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 36.00 | 36.74 | 35.48 |
| Only index persons | 35.04 | 36.02 | 34.48 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 354 | 158 | 196 |
| Unadjusted period prevalence (%) | 0.08 | 0.06 | 0.10 |
| Median age at first event (years) | 37.31 | 37.65 | 37.04 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint K11_PSC_COLITIS_STRICT and mortality.
Females
No dataMales
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_PSC_COLITIS_STRICT | 2.174 [1.71, 2.76] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 793 males with K11_PSC_COLITIS_STRICT died.
Mortality risk
Mortality risk for people of age
years, who have K11_PSC_COLITIS_STRICT.| N-year risk | Females | Males |
|---|---|---|
| 1 | No data | 0.422% |
| 5 | No data | 2.357% |
| 10 | No data | 5.82% |
| 15 | No data | 11.196% |
| 20 | No data | 19.291% |
Relationships between endpoints
↥Index endpoint: K11_PSC_COLITIS_STRICT – Colitis, primary sclerosing, strict definition
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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