Colitis, primary sclerosing, strict definition

K11_PSC_COLITIS_STRICT

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

  • K11_CHOLANGI
2140

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

360

6. Filter based on genotype QC (FinnGen only)

354

Control definitions (FinnGen only)

Control conditions not K11_CHOLANGI

Extra metadata

Level in the ICD hierarchy C
First used in FinnGen datafreeze DF3

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1356 487 865
Only index persons 1293 469 824
Unadjusted period prevalence (%)
Whole population 0.02 0.01 0.02
Only index persons 0.03 0.02 0.03
Median age at first event (years)
Whole population 36.00 36.74 35.48
Only index persons 35.04 36.02 34.48

-FinnGen-

Key figures

All Female Male
Number of individuals 354 158 196
Unadjusted period prevalence (%) 0.08 0.06 0.10
Median age at first event (years) 37.31 37.65 37.04

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

Mortality – FinRegistry

Association

Association between endpoint K11_PSC_COLITIS_STRICT and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
K11_PSC_COLITIS_STRICT 2.174 [1.71, 2.76] < 0.001
Birth year 0.986 [0.98, 1.0] 0.004

During the follow-up period (1.1.1998 — 31.12.2019), 113 out of 793 males with K11_PSC_COLITIS_STRICT died.

Mortality risk

Mortality risk for people of age

years, who have K11_PSC_COLITIS_STRICT.

N-year risk Females Males
1 No data 0.422%
5 No data 2.357%
10 No data 5.82%
15 No data 11.196%
20 No data 19.291%

Relationships between endpoints

Index endpoint: K11_PSC_COLITIS_STRICT – Colitis, primary sclerosing, strict definition

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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