temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
1110 |
4. Check minimum number of eventsNone |
1110 |
5. Include endpointsNone |
1110 |
6. Filter based on genotype QC (FinnGen only) |
1086 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
5
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M31
Name in latin
Arteritis gigantocellularis cum polymyalgia reumatica
Similar endpoints
↥List of similar endpoints to
Temporal arteritis
based on the number of shared cases.
Similar with more cases:
- Giant cell arteritis with polymyalgia rheumatica
- Giant cell arteritis
- Other necrotizing vasculopathies (FG)
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7500 | 5041 | 2416 |
| Only index persons | 6755 | 4573 | 2182 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.12 | 0.14 | 0.07 |
| Only index persons | 0.14 | 0.17 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 72.49 | 72.98 | 71.41 |
| Only index persons | 71.88 | 72.38 | 70.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1086 | 670 | 416 |
| Unadjusted period prevalence (%) | 0.24 | 0.26 | 0.21 |
| Median age at first event (years) | 69.75 | 69.39 | 70.33 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_TEMPARTERIT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TEMPARTERIT | 1.308 [1.18, 1.44] | < 0.001 |
| Birth year | 0.993 [0.99, 1.0] | 0.119 |
During the follow-up period (1.1.1998 — 31.12.2019), 1563 out of 4350 females with M13_TEMPARTERIT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_TEMPARTERIT | 1.385 [1.19, 1.61] | < 0.001 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2033 males with M13_TEMPARTERIT died.
Mortality risk
Mortality risk for people of age
years, who have M13_TEMPARTERIT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.127% | 0.275% |
| 5 | 0.736% | 1.533% |
| 10 | 1.731% | 3.506% |
| 15 | 3.541% | 6.783% |
| 20 | 6.176% | 11.54% |
Relationships between endpoints
↥Index endpoint: M13_TEMPARTERIT – Temporal arteritis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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