temporal arteritis: Giant cell arteritis (GCA) is a large vessel vasculitis predominantly involving the arteries originating from the aortic arch and especially the extracranial branches of the carotid arteries.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
473681 |
1. Apply sex-specific ruleNone |
473681 |
2. Check conditionsNone |
473681 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
1248 |
4. Check minimum number of eventsNone |
1248 |
5. Include endpoints |
1248 |
6. Filter based on genotype QC (FinnGen only) |
1216 |
Control definitions (FinnGen only)
Control exclude
M13_SYSTCONNECT
Extra metadata
Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Similar endpoints
↥List of similar endpoints to
Giant cell arteritis
based on the number of shared cases.
Similar with more cases:
- Other necrotizing vasculopathies
- Systemic connective tissue disorders
- Autoimmune diseases related-to ILD
- Diseases of the musculoskeletal system and connective tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 9069 | 6071 | 2933 |
| Only index persons | 7652 | 5164 | 2488 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.17 | 0.08 |
| Only index persons | 0.16 | 0.19 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 72.33 | 72.72 | 71.45 |
| Only index persons | 71.52 | 71.93 | 70.66 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 1216 | 740 | 476 |
| Unadjusted period prevalence (%) | 0.27 | 0.29 | 0.24 |
| Median age at first event (years) | 69.71 | 69.36 | 70.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
Mortality – FinRegistry
↥Association
Association between endpoint M13_GIANTCELL and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_GIANTCELL | 1.291 [1.17, 1.42] | < 0.001 |
| Birth year | 0.992 [0.98, 1.0] | 0.054 |
During the follow-up period (1.1.1998 — 31.12.2019), 1604 out of 4624 females with M13_GIANTCELL died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| M13_GIANTCELL | 1.32 [1.14, 1.52] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 859 out of 2239 males with M13_GIANTCELL died.
Mortality risk
Mortality risk for people of age
years, who have M13_GIANTCELL.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.134% | 0.217% |
| 5 | 0.717% | 1.508% |
| 10 | 1.759% | 3.57% |
| 15 | 3.324% | 7.161% |
| 20 | 5.818% | 12.419% |
Relationships between endpoints
↥Index endpoint: M13_GIANTCELL – Giant cell arteritis
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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